Seems that some time ago, there was one that REPLICATED at a rapid rate, which in time would cause the ability of a NONE BOOTABLE partition.
also if you use AVAST AV... there is a part of it that (grows quite fast) do not remember exactly where but under AVAST... I used a special bat file to remove when I used AVAST... to keep from growing..
Other than also cleaning the TEMP and TMP files.. and checking the AVG directory for its files...