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Although a great number of Win XP programs will run with Vista, there are a few that will run , but with some issues or won’t run at all no matter what you do. What would you do is this situation? Here are some suggestions:
First, don’t go out to purchase an updated version of the program, at least not yet. Remember that we are still dealing with a Beta version of Vista; there’s always a chance that your program will work once the final version rolls around. Another reason not to purchase an updated version is that by the time Vista rolls around, software developers may have already a Vista compatible update. However, do check for updates before proceeding, as there’s a chance you can download a free update.

If you cannot find and update, the next step is to change the compatibility for the program. There are two ways to change the compatibility settings: Manually or using the Program Compatibility Wizard.

To run the wizard, click Start, Help and Support, the type Compatibility Wizard and select Run the Program Compatibility Wizard. Then just follow the instructions in the wizard.

To change compatibility settings manually, simply right-click the program’s icon, click on Properties, then click the Compatibility tab. You can change the compatibility mode by first placing a check mark to the left of “Run this program in compatibility mode for:”, then selecting the compatible Windows operating system for the program.

You can also check mark the following settings:
Run in 256 colors: Uses a limited set of colors in the program. Some older programs are designed to use fewer colors.
Run in 640 × 480 screen resolution: Runs the program in a smaller-sized window. Try this setting if the graphical user interface appears jagged or is rendered improperly.
Disable visual themes: Disables themes on the program. Try this setting if you notice problems with the menus or buttons on the title bar of the program.
Disable desktop composition: Turns off transparency and other advanced display features. Choose this setting if window movement appears erratic or you notice other display problems.
Disable display scaling on high DPI settings: Turns off automatic resizing of programs if large-scale font size is in use. Try this setting if large-scale fonts are interfering with the appearance of the program.
Privilege level: Runs the program as an administrator. Some programs require administrator privileges to run properly. If you are not currently logged on as an administrator, this option is not available.
Show settings for all users: Lets you choose settings that will apply to all users on this computer.

One more thing; Do not ignore the following WARNING that appears when you start the wizard: Do not use the Program Compatibility Wizard on older antivirus programs, disk utilities, or other system programs because it might cause data loss or create a security risk.
Although you might get the program to work, the antivirus program might not protect your PC against viruses for example, or the Register repair program might cause more harm than good, and so forth. There are many antivirus and a few utility programs compatible with Vista, so don’t take a chance. Happy computing!